Fresh analysis reveals that people who stop using popular GLP-1 drugs like Mounjaro or Wegovy may regain shed pounds far faster than those who halt conventional diet and exercise regimens.
Research printed in a prominent medical journal shows that while obese individuals frequently drop substantial amounts of their body weight while on the medication, the weight comes back at an estimated rate of 0.8 kg per month once they quit.
"Users buying such medications should be informed of the potential of quick rebound weight gain when the therapy is stopped," stated researcher Dr. Susan Jebb.
That rate of recovery implies a reversion to original mass within about one and a half years.
Comparing Treatments
The study, which looked at 37 of trials involving thousands of patients, contrasted the outcomes of the injectable medications with conventional dieting.
Researchers note that individuals who lose weight through dieting generally experience a slower creep back—around 0.1 kg a month—after stopping.
Explaining the Rapid Regain
Doctors believe the mode of action of the drugs explains the accelerated regain.
These medications copy a body's own chemical called GLP-1, which helps regulate appetite.
"Artificially providing GLP-1 concentrations far above than the body's typical production might result in the body to produce less of its endogenous GLP-1, and could reduce responsiveness to its actions," noted Dr. Adam Collins, a dietetics expert.
"Stopping of this GLP-1 'fix' leads to hunger is unsuppressed, making binge eating much more probable."
A Lifelong Condition?
Medical guidelines advise the jabs for people with obesity-related health risks, accompanied by prescribed lifestyle changes.
Many experts contend that, given the high risk of relapse, the treatment is often long-term.
This opinion is reinforced by drug manufacturers, who state that the findings "emphasize the chronic character of excess weight," akin to managing diseases like high blood pressure.
User Testimonies
Individuals who have discontinued the jabs explain a intense resurgence of cravings.
"It felt as if something that goes on and I was suddenly extremely hungry," recalled an individual.
This difficulty is worsened if individuals have not established lasting lifestyle or habit modifications during therapy.
Significant Interest
Survey data indicate that millions of people in the UK have tried weight-loss jabs in the last 12 months, with demand continuing to grow.
- Use is greater among females compared to men.
- The 40s and 50s age group shows the highest level of interest.
- Many obtain the drugs through private prescriptions rather than public health services.
In conclusion, clinicians emphasize that while these medications are powerful agents for weight loss, they are not a magic cure and maintained weight loss relies on integrated behavioural support.
